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    Research infrastructures

    Microcalorimetry: TAM-III

    Location

    Research Support Building (CACTUS). Lugo
    Campus Lugo s/n, 27002
    Lugo
    Schedule
    Monday to Friday, from 10 a.m. to 2 p.m. and from 4 p.m. to 6 p.m.
    • Operational equipment
    Every chemical, physical or biological process is accompanied by the production or consumption of heat. Microcalorimetry is a very versatile technique to study thermal activity in the form of heat, heat flow and heat capacity.

    • TAM-III is a multi-channel microcalorimeter with a thermostat that monitors the bath temperature to an accuracy of 0.0001 °C. This thermostat uses mineral oil that rapidly dissipates heat and minimises temperature gradients in the system. Temperature fluctuations in the TAM-III are ±10 µK in the 15-150 °C range and the 24 h drift is around ±100 µK. It can be used in isothermal, step-isothermal or temperature gradient mode.

      Instruments

      TAM-III Multicalorimeter (TA Instruments) with six 4 mL capacity mini-calorimeters. Glass ampoules can be used for experiments at low temperature ranges, or stainless-steel ampoules for samples that react with glass, or when working at higher temperatures or suspected outgassing during the test.

    • The most common applications are in:

      • Pharmaceuticals: polymorphisms, drug-excipient compatibility, stability, amorphicity and crystallinity.
      • Materials: Stability and compatibility.
      • Life sciences: microbial activity, detection of microorganisms in blood, dose-response curves.

    • Unidade de Análise Instrumental

      Edificio de Apoio á Investigación (CACTUS) Lugo