Nutrigenetics and nutrigenomics

LEARNING OUTCOMES
- List the techniques used in the study of Nutrigenomics.
- Identify the molecular mechanisms through which nutrients can regulate the expression of certain genes.
- Identify molecules and genes that can be used as biomarkers for the prevention, diagnosis and monitoring of diseases.
-Distinguish the genotypes associated with various responses to food.

RECOMMENDED PREREQUISITES
Genetics I, Genetics II, Biochemistry I, Biochemistry II, Food Biotechnology.

Contents:

Expository classes
1. Gene-diet interaction. Nutrigenetics, nutrigenomics, epigenetics, epigenomics
2. Nutrigenomics of macro and micronutrients and bioactive compounds from foods
3. Molecular nutrition and human gastrointestinal microbiota
4. Application of nutrigenomics in the food industry.
5. Omic technologies for application in Nutrigenetics and nutrigenomics

- SEMINARS
There will be 8 hours of seminars in which group work will be done on specific topics of the subject through Research assignments, including research on a topic through Copilot or another AI tool available to the uSC or Misrosoft 365. The tasks will be delivered in the CV.
- Webinars. Meetings with Professionals specializing in both innovative industries and analysis laboratories, depending on availability

- PRACTICES
I. COMPUTER PRACTICES
5 hours of practice will be carried out on the computer in two sessions lasting 150 minutes each.
General objective: Application of omics technologies in the detection, identification, authenticity, traceability of nutraceuticals and probiotics
1. in-silico analysis using genomic tools and DNA barcodes for the study of authenticity and traceability of nutraceuticals (2 hours)
2. in-silico analysis using genomic and proteomic tools for the detection and identification of probiotics and new generation probiotics (2 hours)
Under no circumstances will late deliveries be accepted.
II. FIELD PRACTICES (6 hours). It will be done to visit companies in the sector (AMSLab among others, Meraki)

TUTORING
They will be carried out in order to clarify doubts that arise during the development of the subject.

Basic:
Principles of Nutrigenetics and Nutrigenomics. 1st Edition. Fundamentals of Individualized Nutrition (2019) Editors: Raffaele Caterina Alfredo Martinez Martin Kohlmeier. eBook ISBN: 9780128045879. Hardcover ISBN: 9780128045725. Academic Press

Nutrigenomics: How Science Works (2020) Authors: Carlberg, Carsten, Ulven, Stine Marie, Molnár, Ferdinand. ISBN-13 : 978-3030369477. Springer

Human Epigenetics: How Science Works (2019) Carlberg, Carsten, Molnár, Ferdinand. ISBN-13 : 978-3030229061. Springer

Genomics, Proteomics and Metabolomics in Nutraceuticals and Functional Foods, Second Edition. (2015) Editor(s): Debasis Bagchi, Anand Swaroop, Manashi Bagchi. Print ISBN:9781118930427. Online ISBN:9781118930458. John Wiley & Sons, Ltd.

complementary:

Nutrigenomics and Proteomics in Health and Disease: Towards a Systems‐Level Understanding of Gene–Diet Interactions, Second Edition. (2017) Eds: Martin Kussmann, Patrick J. Stover. Print ISBN:9781119098836. Online ISBN:9781119101277. John Wiley & Sons Ltd.

Nutrigenomics and Proteomics in Health and Disease: Food Factors and Gene Interactions. (2009) Eds: Yoshinori Mine, Kazuo Miyashita, Fereidoon Shahidi. Print ISBN:9780813800332. Online ISBN:9780813807263. Wiley‐Blackwell

Probiotics, Prebiotics, and Synbiotics Bioactive Foods in Health Promotion (2015) Ed. Ronald Watson, Victor Preedy. Hardcover ISBN: 9780128021897. eBook ISBN: 9780128023716. Academic Press

The Gut Microbiome in Health and Disease Editors (2018) Haller, Dirk ISBN: 9783319905440. Ed: Springer

Competencies
List of learning outcomes:
Knowledge/contents: Con01, Con05.
Skills/skills: H/D02, H/D03, H/D05, H/D07, H/D08, H/D12, H/D14
Competencies: Comp01, Comp02, Comp03, Comp04, Comp05

2.1. Knowledge/content
• Con01: Know the most important concepts, methods and results of the different branches of Biotechnology.
• Con05: Know the molecular bases and techniques for manipulating genetic information in microorganisms, animals and plants and understand their applications in different biotechnological fields.

2.2. Skills/skills
• H/D02: Search, process, analyze/interpret and synthesize relevant information and results from various sources and obtain conclusions on topics related to Biotechnology.
• H/D03: Organize and plan your work.
• H/D05: Work as a team.
• H/D07: Initiative, entrepreneurial spirit and adaptation to new situations (resilience).
• H/D08: Leadership and team management.
• H/D12: Know how to apply instrumental techniques and work protocols in a laboratory, applying regulations and techniques related to safety and hygiene, waste management and quality.
• H/D14: Know how to analyze and design biotechnological industrial processes and apply them to the improvement of processes and products with sustainability and quality management criteria.

23. Competencies
• Comp01: That students have the ability to gather and interpret relevant data (normally within their area of ​​study) to make judgments that include reflection on relevant issues of a social, scientific or ethical nature.
• Comp02: That students are able, both in writing and orally, to debate and transmit information, ideas, problems and solutions related to Biotechnology to both a specialized and non-specialized/general audience.
• Comp03: That students have developed those learning skills necessary to undertake further studies with a high degree of autonomy.
• Comp04: That students know how to apply the theoretical-practical knowledge acquired in the degree in a professional manner and are competent in posing/solving problems, as well as in the elaboration/defense of arguments in both academic and professional contexts related to the innovation and the biotechnology industry.
• Comp05: Study and learn autonomously, with organization of time and resources, new knowledge and techniques in Biotechnology and acquire the ability to work as a team.

TEACHING METHODOLOGY
- The expository classes will be taught in the form of master classes in which the teacher will explain the concepts of the subject with the support of audiovisual and computer media, and may have different formats (theory, general problems or examples, general guidelines of the subject), promoting student participation through Research assignments on the topic will be carried out using Copilot or another AI tool..

- The interactive classes will consist of a seminar in small groups, in which practical and specific cases of the subject will be studied. Active participation of the students is required. Compulsory attendance.

- In practical classes in the computer room, students will use programs and databases relevant to the subject. Compulsory attendance. Work in small groups.

- Field trips. Assistance is mandatory

- The tutorials (individual or in a small group) will be dedicated to clarifying doubts, providing information or guiding the students, as well as to know the progress in the acquisition of skills. Tutorials, as well as to maintain direct communication both between the students themselves and between them and the teacher, may be carried out through the Virtual Campus forum, through Ms. Teams or through email.

CONTINUOUS EVALUATION: 40%
EVALUATION Seminars: (10%)
Practical EVALUATION: (10%)
FINAL EVALUATION: 40%

1. Continuous evaluation (40% of the final grade): the personal and collaborative work of the students will be collected through active participation in the classroom and tests, and outside the classroom through the tools of the USC virtual campus that will include:
- Research assignments including research on a topic using Copilot or another AI tool available to the USC or Microsoft 365 with assignment delivery on the CV
, with a time of 1 week to submit homework. In some classes, at the end of class a Research assignment on the topic will be carried out using Copilot or another AI tool that will be delivered in class on the CV.
- asynchronous quizzes (one asynchronous multiple choice quiz for each week of class to solve over 1 week,...).

2. Evaluation of the seminars (10% of the final grade): Presentations will be made on the topics. Asking questions will be valued. The task will be delivered in the CV

3. Evaluation of field practices and practices. Attendance will be mandatory and evaluation will be through assignment delivery. It is not necessary to dispense with assistance.

4- FINAL evaluation of theoretical-practical knowledge (it will account for 40% of the final grade). It will consist of the delivery of a work in Homework Submission and its discussion in the Forum through questions with comments (between 200 and 250 words) and well-reasoned answers (between 250 and 300 words. Copilot can be used to formulate questions and answers .

EVALUATION OF LEARNING OUTCOMES:
- Final exam: Knowledge/Contents: Con01, Con05
- Seminars: Skills/Abilities: H/D02, H/D03, H/D05, H/D07, H/D08; Competencies: Comp01, Comp02, Comp03, Comp04, Comp05
- Practices: Skills/Abilities: H/D12, H/D14; Competencies: Comp04

REPEATER EVALUATION:
- They will be exempt from carrying out the internships during an academic year, maintaining the grade from the previous year, unless they wish to do them again. In everything else, the evaluation system described above will be applied.

TIPO DE GRUPO HORAS PRESENCIALIDAD (%)
Docencia teórica 20 100
Docencia interactiva seminario 8 100
Docencia interactiva laboratorio/aula informática 5 100
Prácticas de campo 6 100
Docencia clínica
Tutorización en grupo reducido 1,5 100
Trabajo personal del alumnado 72 0


Individual work: 72 h

Recommendations for the study of the subject
-Participate actively, constructively and respectfully in classes and seminars.
-Prepare and complement the contents that are working on the subject with the basic bibliography and complementary recommended.
-Developing habits of autonomous search for scientific information.
-To take advantage of the available resources for the student, from the university library.
-Use appropriate tutorials to know in detail the recommendations of the teacher and clarify any doubts that arise in the learning process.

The subject is taught in the two official languages ​​of the autonomous community.

English language is recommended

-The admission of students enrolled in the practical laboratory requires that they know and comply with the General Safety Standards in the practical laboratories of the University of Santiago de Compostela. The aforementioned information is available on the USC website http://www.usc.es/export9/sites/webinstitucional/gl/servizos/sprl/desca… -seguroe-nos-laboratorios-de-practicas.pdf).