ECTS credits ECTS credits: 6
ECTS Hours Rules/Memories Hours of tutorials: 3 Expository Class: 27 Interactive Classroom: 21 Total: 51
Use languages Spanish, Galician
Type: Ordinary Degree Subject RD 1393/2007 - 822/2021
Departments: Biochemistry and Molecular Biology
Areas: Biochemistry and Molecular Biology
Center Faculty of Biology
Call: Second Semester
Teaching: With teaching
Enrolment: Enrollable
- Identify the central routes of metabolism and its regulation in different organisms.
- Learn to integrate the different metabolic pathways in the context of the whole of the body.
- Apply knowledge about the metabolism of the genetic information.
- Apply knowledge about the synthesis mechanism of proteins and their post-biosynthesis evolution.
- Identify the relevance of energy and material balances of metabolic pathways.
- Learn design functional modifications of metabolic pathways biotechnological purposes.
• EXPOSITORY CLASSES (THEORY PROGRAM, 28H)
Protein Synthesis*
Lesson 1. Translation of the genetic message and post-biosynthesis evolution of proteins (3h).
Aerobic and bioenergetic intermediary metabolism pathways and bioenergetics
Lesson 2. Oxidation of acetyl-CoA: Cycle of citric acid cycle (1.5h).
Lesson 3. Electron transport and oxidative phosphorylation (3h).
Carbohydrate Metabolism
Lesson 4. Catabolism of carbohydrates. Glycolysis (2.5h).
Lesson 5. Gluconeogenesis and the pentose phosphate pathway (2.5h).
Lesson 6. Glycogen metabolism (1.5 h).
Lipid Metabolism
Lesson 7. Catabolism of lipids. Fatty acid oxidation and metabolism of ketone bodies (2.5h).
Lesson 8. Biosynthesis and regulation of fatty acids metabolism (1.5h).
Lesson 9. Biosynthesis of glycerides and sphingolipids (1.5h).
Lesson 10. Terpenes and steroids metabolism (1.5h).
Metabolism of amino acids and nucleotides
Lesson 11. Degradation of proteins and catabolism of amino acids (2h).
Lesson 12. Biosynthesis of amino acids and related metabolites (2h).
Lesson 13. Metabolism of nucleotide (1.5h).
Integration and interrelationships in metabolic pathways
Lesson 14. Integration and coordination of metabolic processes (1.5h).
*Except for the topic dedicated to protein synthesis, and those dedicated to nucleic acids and their metabolism (DNA structures in chromatin and chromosomes, RNAs and gene expression and its regulation, as well as replication processes, transcription, repair, and recombination) will be explained in the subjects of Genetics I and II.
In the subject of Plant Physiology, photosynthesis, photosynthetic electron transport and photophosphorylation and carbohydrate biosynthesis in plant cells are explained. And, in Microbiology I, the subject related to the cycle and nitrogen fixation is explained.
• INTERACTIVE CLASSES (SEMINARS, 15h)
Thematic seminars/exposition (reinforcement and expansion of specific aspects of the subject; 7.5h) and participatory (posing and resolving issues on the subject's syllabus; 7.5h).
• INTERACTIVE CLASSES (LABORATORY, 6h)
In two 3-hour sessions, purification and enzymatic analysis and a study of alcoholic fermentation will be carried out (practices 1 and 2).
• TUTORIAL CLASSES (2h)
Consultation and clarification or resolution of doubts.
• Exam and exam review (3h)
Basic Bibliography
- Berg, J.M., Tymoczko, J.L., Gatto, G.J.Jr & Stryer, L. 2019. Biochemistry. Nine ed. New York.
W.H. Freeman and Compnay.
- Garret, R.H. & Grisham, C.M., 2024. Biochemistry. 7th ed. Cengage Learning Inc.
- McKee, T., y McKee, J.R., 2020. Bioquímica. Las bases moleculares de la vida. 7ª ed. México:
McGraw-Hill/Interamericana Editores. Disponible “on line”:
https://accessmedicina-mhmedical-com.ezbusc.usc.gal/book.aspx?bookid=29…
- Mathews, C., Van Holde, K.E., Appling, D.R. & Anthony-Cahill, S.J., 2013. Bioquímica. 4ª ed.
Madrid: Pearson.
- Nelson, D.L. & Cox, M.M., 2021. Lehninger Principles of Biochemistry. 8ª ed. New York:
Macmillan International.
- Voet, D., Voet, J.G. & Pratt, Ch., 2016. Fundamentos de Bioquímica. 4ª ed. Buenos Aires:
Editorial Médica Panamericana.
Complementary Bibliography
- Alberts, B. et al., 2022. Molecular Biology of the Cell. 7th ed. W.W. Norton & Company, Inc, New York.
- Bhagavan, N.V., Chung Eun-Ha. 2015. Essentials of Biochemistry. With Clinical classes.
2nd edition. Academic Press. Disponible “on line”:
https://www.sciencedirect.com/book/9780124166875/essentials-of-medical-…
- Meissenberg, G., Simmons, W.H. 2018. Principios de Bioquímica Médica. 4ª edición.
Elsevier España, S.L.U. Disponible “on line”:
https://www.clinicalkey.com/student/content/toc/3-s2.0-C20170026563
- Rodwell, V.W., Bender, D.A., Botham, K.M., Kennelly, P.J. y Weil, P.A., 2018.
Harper Bioquímica ilustrada. 31ª ed. México: McGraw-Hill/Interamericana.
Disponible “on line”:
https://accessmedicina-mhmedical-com.ezbusc.usc.gal/Book.aspx?bookid=27…
LIST OF LEARNING OUTCOMES
Knowledge/contents: Con02
Skills/ablilities: HD01, HD03, HD05
Competencies: Comp02, Comp04, Comp05
• Expository classes.
Master classes for the presentation of the contents of the theoretical program of the subject with the use of blackboard supported by computer presentations.
• Interactive classes:
(a) Seminars. Evaluable, non-obligatory and collaborative learning to deepen/expand and reinforce specific concepts and topics presented in the expository classes and enhance learning through the student's participation in the class orally or in writing (see evaluation system).
(b) Laboratory practices. The objective of the practices will be to familiarize the students with some of the methodologies typical of a Biochemistry laboratory. The practices will be mandatory.
• Tutorial classes. Clarification and resolution of doubts about the matter.
LEARNING EVALUATION SYSTEM
(A) (Final exam). Mandatory evaluable activity complementary to continuous evaluation.
The contents of the theoretical program will be evaluated through a face-to-face written exam (final exam). The maximum grade obtained in the exam (10 points) is equivalent to 75% of the final grade and as long as a minimum of 85% of the questions have been answered. Furthermore, the exam must be compensated in terms of the grade obtained in answers to objective questions (test type, terms relationship tables.....), with respect to that achieved in questions whose answer involves justifying, arguing, reasoning and relate concepts.
(B) Continuous evaluation
(a) Interactiva Seminars. Non-mandatory evaluable activity that could involve the presentation and/or presentation of work, to reinforce knowledge of specific topics, preparation of maps of metabolic routes to be delivered and/or participation (oral and/or written) of the student in the class:
- identifying/interpreting/describing and explaining images/figures/schemes related to or presented in the contents of the expository classes.
- responding to issues/questions/exercises posed (by the teacher) in the class itself or previously presented and accessible to students through the virtual classroom and that are related to each of the lessons or thematic blocks of the subject.
This activity will be graded from 0 to 10 points and the maximum achievable grade (1.5 points) will account for 15% of the final grade for the subject, and as long as at least a 4.7 has been achieved in the final exam (see final evaluation).
A minimum attendance of 80% is required to be qualified in this section.
- In the case of repeating students, they will find themselves in the same circumstances as those enrolled for the first time, regarding this activity.
(b) Laboratory practices. Mandatory evaluable activity.
- Attendance at all practical sessions will be mandatory to pass the subject. The work in the laboratory will be assessed and will be evaluated by submitting an assignment or completing an online questionnaire through the virtual classroom (10% of the total grade for the subject). Unexcused absences will result in a grade of NOT APPROPRIATE.
- Students must obtain a PASS grade (5) in the practices to pass the subject.
- The grade for the practice will be maintained during one course, which will mean that repeating students will not have to repeat the practice the following year.
- Repeaters. Repeating students will be exempt from doing the practices, but the grade from the seminars from the previous year will not be retained.
(C) Final evaluation
The final grade will be obtained as the weighted average of the partial grades obtained in: (A) the content exam (final) of the expository classes (graded from 0 to 10 points and with the previously mentioned conditions) and which corresponds to a 75 % of the total final grade and (B) of the continuous evaluation corresponding to the interactive classes (25% of the total), taking into account that the grade obtained in the seminars can only be added to the final exam if a minimum of 4.7 points and the requirements demanded in the practices have been met.
- Students who do not pass the subject in the ordinary call may take the recovery opportunity while maintaining the continuous evaluation grade (exclusively the evaluation dependent on the final exam will be repeated).
- Students who fail the subject and have to repeat it will be able to maintain the practice grade during the following course, as long as they have completed the practices.
LEARNING EVALUATION SYSTEM
(A) Final exam
Knowledge/ Contents: Con02
Skills/Abilities: H/D01, H/D05
Competencies: Comp02, Comp05
(B) Continuous evaluation
(a) Seminars
Knowledge/ Contents: Con02
Skills/Abilities: H/D01, H/D03
Competencies: Comp02, Comp04
(b) Laboratory practices
Skills/Abilities: H/D01, H/D05
Competencies: Comp02, Comp05
PRESENTIAL WORK IN AULA
Lectures (expository) 28h
Seminars (interactive) 15h
Laboratory practices (interactive) 6h
Tutorials 2h
3h exam
Total Work in the classroom 54h
PERSONAL WORK
Individual Studio 96h
• Attendance at all teaching activities.
• Use of the recommended bibliography and what was presented in the virtual classroom, if applicable.
• Participation in the corresponding classes, responding orally and/or in writing to the issues/questions posed by the teacher, both in the class itself and in those presented in the different lessons of the theoretical program and those specific to the seminars.
• Go deeper into the aspects of the subject indicated and presented by the teacher in the corresponding classes.
• Make summaries/schemes or scripts that synthesize the important contents of each of the program lessons, trying to combine and relate different aspects that are explained in each of them.
• Develop metabolic map(s) that allow the central metabolic pathways to be brought together in different physiological situations that allow relating, visualizing and clarifying aspects of the subject explained in separate blocks.
• Self-assessment of understanding of the contents. The student should try to generate, by himself and using the recommended bibliography, a catalog of questions and answers in a manner appropriate to the syllabus.
• Make use of tutorials for any type of question related to the subject.
• It is recommended that for a better understanding of the subject of biochemistry II you have prior knowledge of subjects such as biochemistry I, genetics I/II, cell biology, animal and plant physiology, microbiology, in addition to basic notions of chemistry (organic and inorganic ).
• In the theoretical material explained during the course there could be variations with respect to the program presented in the teaching guide (in the order of time and/or incorporation of new concepts and most recent updates).
• The virtual campus will be used to leave information related to the subject and that may be useful to students.
• In cases of fraudulent completion of exercises or tests, the provisions of the "Regulations for evaluating students' academic performance and reviewing grades" will apply.
• The preferred communication channels will be email and individual tutorials. If necessary, communication can be established through MS-Teams.
Primitivo Barja Francisco
Coordinador/a- Department
- Biochemistry and Molecular Biology
- Area
- Biochemistry and Molecular Biology
- Phone
- 881816931
- primi.barja [at] usc.es
- Category
- Professor: University Lecturer
Maria Lourdes Dominguez Gerpe
- Department
- Biochemistry and Molecular Biology
- Area
- Biochemistry and Molecular Biology
- ml.dominguez.gerpe [at] usc.es
- Category
- Professor: Temporary supply professor to reduce teaching hours
| Tuesday | |||
|---|---|---|---|
| 19:00-20:00 | Grupo /CLE_01 | Spanish | Classroom 08. Louis Pasteur |
| Wednesday | |||
| 19:00-20:00 | Grupo /CLIS_01 | Spanish | Classroom 08. Louis Pasteur |
| 05.22.2025 16:00-20:00 | Grupo /CLE_01 | Classroom 04: James Watson and Francis Crick |
| 07.02.2025 16:00-20:00 | Grupo /CLE_01 | Classroom 03. Carl Linnaeus |