Immunology

The main objective of this course is that students have a current and comprehensive immune system function and to know the fundamentals of the immune response, cells and molecules that make up the immune system and the communication mechanisms and cooperation existing between the different cell types.
Specific objectives:
- Understand the physiology of the immune system as well as molecular and cellular components.
- Know the basic mechanisms of recognition and effector mechanisms of innate and adaptive immune response.
- Know and understand the role of the immune system defending the body against infection with different pathogens. Understand the immune system relation with cancer processes in transplant rejection and allergic process.
- Know the therapeutic uses of action on the immune system and the ability to manipulate the immune response.

The program of lectures (26) is:
1. Introduction to immunology. Components of the immune system. Leukocyte trafficking.
2. Innate Immunity: Phagocytes and their receptors. Complement, its ligands and its receptors.
3. Antibodies, their ligands and their receptors.
4. B lymphocytes and their receptor for antigen.
5. The generation of the diversity of B and T lymphocytes.
6. Histocompatibility molecules: ligands and receptors.
7. Presentation of antigens to T lymphocytes.
8. T lymphocytes and their receptor for antigen.
9. The generation of the restricted repertoire of T lymphocytes.
10. The generation of effector T and B lymphocytes.
11. Immunological messaging: cytokines and their receptors.
12. Immunity in action against viruses, bacteria, fungi and parasites.

Topic 11, 12 will take 1 hour, topic 1 and 2 will take 4 hours, and the rest of the topics will last 2 hours.

In the laboratory practices (8h), the proposed experiments are conceptually correlative to the theoretical topics of the subject. The students will have to carry out a series of experimental tests, collect the results obtained and analyze them properly to answer the questions and exercises set out in the practice script. The internship program will be carried out in person / virtual according to the scenarios, it is: Recognition of the component cells of the immune system and determination of cell viability. Determination and study of lymphocyte subpopulations by Flow Cytometry.

In the interactive seminar classes, a 4-hour seminar will be held and applied questions and / or clinical cases will be asked of the knowledge developed in the lecture classes.

The tutorials (1h) will be oriented to the resolution of the particular doubts generated in the lectures and their application in pathological cases and / or their therapy.

Básic:

- Abul K. Abbas, Andrew H. Lichtman, Shiv Pillai, 2022, Inmunología celular y molecular, 10ª ed.,Barcelona:Elsevier, cop. 2022.

- Jenni Punt, Sharon A. Stranford ; Edición 2020, Kuby inmunología 8ª ed. McGraw Hill Interamericana.

- Abbas, A.K., Lichtman, A.H. y Pillai, S., 2012. Inmunología celular y Molecular. [Recurso electrónico]. ed. Barcelona: Elsevier. Acceso restrinxido a usuarios USC <https://www.dawsonera.com/terms/show?dest=https%3A%2F%2Fwww.dawsonera.c…>.

- Abbas, Abul K. Andrew H. Lichtman, Shiv Pillai, 2020, Inmunología básica : funciones y trastornos del sistema inmunitario, 6ª ed. Barcelona : Elsevier, cop.

- Regueiro González, J.R. et al., 2022. Inmunología: biología y patología del sistema inmunitario. 5ª Edición, Madrid: Editorial Médica Panamericana.

Complemmentary:
- K. Murphy, C. Weaver Inmunobiology Janeway, 9ª edición 2017, Garlan science.

- Delves, P.J. et al., 2014, Inmunología: fundamentos., ed. Buenos Aires: Editorial Médica Panamericana.

- Leonardo Fainboim, Jorge Geffner 2011, Introducción a la inmunología humana, Edición 6ª ed., Buenos Aires : Panamericana, cop.

Knowledge/contents: Con01, Con02, Con05
Skills/skills: H/D01, H/D02, H/D03, H/D07, H/D09, H/D10, H/D11H/D12
Competencies: Com01, Com03, Com02, Com05, Com06

The subject is designed to enhance the active learning of students. The individual study will be carried out on the basis of organized and detailed information provided by the teaching staff. The basis for such information will be the recommended basic bibliography, which will be supplemented, where necessary, with additional information.
In reference to the lectures, they are conceived as general introductions to each topic, which will be complemented with the rest of the proposed activities. These activities are: individual study, resolution of questions, preparation of activities proposed in seminars. They will be developed in person in the classroom, attending to all the doubts and clarifications raised by the students. The help material prepared to facilitate the monitoring and understanding of the topics (which includes a summary of the topics explained and the necessary complementary material) is provided in the virtual campus of the USC corresponding to the subject.
The laboratory practices are organized in several sessions where the theoretical contents are applied, through the observation and handling of biological material, instruments, etc., following the protocols prepared for this purpose by the teaching staff.
The tutorials are conceived as a means of coordinating and guiding the individual work of the students.
In the interactive seminar classes, they will be developed in the classroom where applications of the theory will be proposed and solved, exercises, problems, simulations of clinical cases, etc. will be done (PBL problem-based learning). Active participation of the students is required. It is programmed to provide them with information and complementary material (videos, web addresses, etc.) that will allow them a better understanding of the matter.
The interactive laboratory classes will be compulsory in person in the laboratory.
The activities: lectures, seminars and laboratory practices are non-compulsory activities that can be evaluated. And the Final Test is a compulsory activity that can be assessed in addition to the continuous assessment.

1."The evaluation of the subject will be the same for repeaters and non-repeaters, with no notes from previous years being kept. Furthermore, the evaluation will always be the same on both occasions and will consist of the following qualifications for the parts into which the subject is divided:

1.1) Continuous evaluation (20% of the final grade), which in turn is composed of:
-Seminars (10% of the final grade). NON-OBLIGATORY EVALUABLE ACTIVITY.
-Laboratory Practices (10% of the final grade). NON-OBLIGATORY EVALUABLE ACTIVITY. Unexcused absences will result in a qualification of NOT SUITABLE. Control of attendance at in-person activities will be carried out by roll call.

1.2) Final Test (80% of the final grade). MANDATORY EVALUABLE ACTIVITY COMPLEMENTARY TO CONTINUOUS EVALUATION. It will be carried out in person and will consist of an exam with multiple choice questions, questions and exercises, related to the theoretical-practical contents of the subject.

Evaluation of learning outcomes:
-Exam: Con01, Con02, Con05.
-Seminar works/exercises: H/D01, H/D02, H/D03, H/D07, H/D09, H/D10, H/D11.
-Practices: Con05, H/D12, Comp01, Comp03, Comp05, Com06

An average of 112.5 hours of work is considered, of which the face-to-face hours are: 26 hours of expository classes, 8 hours of interactive laboratory classes, 2 hours of interactive seminar classes and 2 hours of exam preparation.
and non-contact hours are: 73.5 hours of dedication to individual study.

The study of the subject in the three scenarios is recommended to be done:Use of recommended readings and the material provided by the teacher, essential for the understanding of matter. Frequent reading and reflection on the subject taught, necessary for the integration of knowledge in this field of science. Interest and attention on new developments in this discipline disseminated through the media, for inclusion and discussion in classes and seminars

The subject will have a virtual classroom on the Moodle platform. Communication with students will be done through email, the Moodle platform and / or through the MS-teams application.
“For cases of fraudulent performance of exercises or tests, the provisions of the regulations for the evaluation of the academic performance of students and the review of grades will apply.” This indicates that the fraudulent performance of any exercise or test required in the evaluation will imply the failing grade in the corresponding call, regardless of the disciplinary process that may be followed against the offending student. Considering fraudulent, among others, the completion of plagiarized work (for example, from classmates or previous courses) or obtained from sources accessible to the public without reworking or reinterpretation and without citations to the authors and sources. The distribution by different means (for example, web pages) and without the teacher's consent, of any teaching material posted in the classroom is also strictly prohibited. virtual.