Neurobiology

-To acquire a basic knowledge about the nervous system and how the transmission of signals takes place, taking into consideration the different levels of organization: cellular-molecular; synaptic; and behavioral circuits
Specific goals:
1. Basic knowledge of the constituents of the nervous system
2. Neuronal signals: how are they generated, how are they passed from one to another, and what they encode.
3. Neurotransmitter-receptor interactions.
4. Analysis and individual study of each neurotransmitter.

Theoretical (26h) Presential 100% compulsory
Expositives
1. Cellular components of nervous tissue (2h).
2. Information processing in dendrites: postsynaptic potentials and subthreshold currents.(4h).
3. Neuronal discharge patterns. Neuronal circuits and neuronal coding.(2h)
4. Ion channels: properties. Molecular biology of voltage-sensitive ion channels (5h).
5. Types of neuronal communication: electrical and chemical synaptic transmission. Chemical neurotransmission: stages. Neurotransmitter release: excitation-secretion coupling. Short-term synaptic plasticity (5h).
6. Neurotransmitter receptors. Neurotransmitter reuptake: transporters (3.5h).
7. Pharmacology and biochemistry of synaptic transmission.(4.5h).

Interactive seminar.(2h+2h). Presential and 100% compulsory
Questions and problems related to the topics of the program (e.g. selectivity, rectification, ion channel blocking).

Labs (9h) Presential and 100% compulsory
Laboratory/computer interactives.
Subthreshold currents. Synaptic function. Models of synapses and circuits. Tutorials: (2h)

Básic

Byrne, John H., Ruth Heidelberger, and M. Neal Waxham. From Molecules to Networks : an Introduction to Cellular and Molecular Neuroscience / [editors], John H. Byrne, Ruth Heidelberger, M. Neal Waxham. 3rd ed. Amsterdam: Academic Press, 2014.

Kandel, Eric R. Principles of Neural Science / Edited by Eric R. Kandel ... [et Al.]. 5th/6th ed. New York: McGrawHill Medical, 2006/2021.

Complementary

Squire, Larry R. Fundamental Neuroscience / Edited by Larry R. Squire ... [et Al.]. 4th ed. Amsterdam ;: Elsevier, 2012.

Nestler, Eric J., Steven E. Hyman, and Robert C. Malenka. Molecular Neuropharmacology : a Foundation for Clinical Neuroscience / Eric J. Nestler, Steven E. Hyman, Robert C. Malenka. 2nd. ed. New York: McGraw-Hill Companies, Medical Pub. Division, 2009.

Brady, Scott, George Siegel, and R. Wayne Albers. Basic Neurochemistry: Principles of Molecular, Cellular, and Medical Neurobiology. San Diego: Elsevier Science & Technology, 2011.

Knowledge: Con01, Con05, Con06, Con09.
Skills: H/D01, H/D,02 H/D03, H/D07, H/D08, H/D09, H/D10, H/D11, H/D12, H/D13, H/D14.
Competences: Com01, Com01 Com03, Com05, Com06.

-Lectures: the teacher will expose and explain to the students the main contents of the subject, encouraging participation, debate and critical opinion of the students in the classroom (attendance 100% compulsory for evaluation).
-Interactive teaching: seminars consisting of written papers and their subsequent oral presentation by all students. In addition, the debate on the contents covered in the subject will be exposed (Attendance 100% compulsory for its evaluation).
-Labs. The analysis and resolution of practical cases/suppositions will be developed, as well as computer simulations (Attendance 100% compulsory for its evaluation).
-Tutorials: students may request individual tutorials (virtual-remote), according to the schedule planned for this task in this teaching program.
-Evaluation tests

Applicable to all students (including repeating students) both in the first and second opportunities.
70% of the final grade- Final test: minimum grade 50% (3.5 points out of 7) to add to the grade obtained in the continuous evaluation.
Knowledge: Con01, Con05, Con06, Con09.
30% of the final grade- Continuous evaluation: minimum grade 50% (1.5 points out of 3) to be added to the grade obtained in the final test. Includes: individual written work (Labs): 15% (compulsory evaluable activity); group written work (Seminars): 15% (compulsory evaluable activity).
Knowledge: Con01, Con05, Con06, Con09. Skills: H/D01, H/D,02 H/D03, H/D07, H/D08, H/D09, H/D10, H/D11, H/D12, H/D13, H/D14. Competencies: Com01, Com01 Com03, Com05, Com06.

Study time and personal work
-4,5 ECTS , 25h/credit: 112.5 h
Theoretical teaching 26h;

Interactive teaching seminar 4h;

Interactive teaching laboratory/computer room 9h;
Mentoring 2h;
Examination 2,5h;

Personal work of the students Exp:54h; Int:15h

-Daily follow up onf the activities, readings and content summaries developed with the objective of concretizing the contents object of study in the program.

-Active participation in all the evaluable sections and keeping up to date the study of the subject.

- Follow-up of the information and materials provided to the students, with the desire to facilitate and know the different teaching scenarios and the necessary mechanisms for its correct development.

-Make use of the Virtual Campus of the subject for the development of the activities programmed by the teaching staff.

-Make use of the tutorial hours.

The students will have available in the virtual campus (Moodle) tools of contents used in lectures and seminars sessions, as well as educational resources for the study and complementary material. Tutorial classroom setup in MS-Teams.