ECTS credits ECTS credits: 3
ECTS Hours Rules/Memories Student's work ECTS: 51 Hours of tutorials: 3 Expository Class: 9 Interactive Classroom: 12 Total: 75
Use languages Spanish, Galician
Type: Ordinary subject Master’s Degree RD 1393/2007 - 822/2021
Departments: Forensic Science, Pathological Anatomy, Gynaecology and Obstetrics and Paediatrics
Areas: Legal and Forensic Medicine
Center Faculty of Medicine and Dentistry
Call: First Semester
Teaching: With teaching
Enrolment: Enrollable | 1st year (Yes)
1. Applications of population genetics in biomedicine
2. Basic theoretical concepts in population genetics
3. Methods for data processing and population genetic research in biomedicine
4. Global patterns of human genetic diversity
5. Statistical analysis methods for each type of genetic marker
6. Population genetics in medical population-based studies (case-control design), pharmacogenetics and pharmacogenomics, etc..
7. Genetic data analysis
8. Bibliography management
1. Concepts on population genetics
. Principles governing the inheritance of genetic characteristics
. Causes of genetic variation between human populations. Mutation and the evolutionary process.
. Natural selection and polymorphisms in human populations
. Processes that change the population structure
. Genetic structure of populations
. Integration of the principles of genetics with the rest of the subjects taught in the master
2. Molecular Anthropology (archaeogenetics) and the study of human variability patterns
. Model "out of Africa" versus multi-regional model
. Models of migration of human populations and current geographic patterns: biomedical implications
. Classic studies in molecular anthropology (erythrocyte antigens, blood groups ABC system, etc..)
. Detailed study of the patterns of genetic variability in human populations
3. Genetic markers in population genetics:
. Autosomal markers: minisatellites, microsatellites and SNPs
. Uniparental inheritance
. Introduction to filogeography
4. Methods of analysis: diversity indices, AMOVA, genetic distances, phylogenetic trees, multivariate methods, frequency maps, population structure, mediate networks, etc..
5. Patterns of human diversity of Y-chromosome markers
6. Patterns of human diversity of mitochondrial DNA
7. The classical concept of 'race'. Errors on the concept of race, their interpretation and use. Human populations.
8. Human populations with particular characteristics (outliers). Gene discovery.
9. Population genetics in biomedical research. General concepts
10. Natural selection in human populations and implications biomedical association studies, farmacogenetics, etc...
11. Mixed population, its estimation and its implications for medical genetics
12. Relationship genes, language and history
13. Databases of genetic markers.
14. Issues on the use of population genetic databases
15. Population genetics as a tool for inferencing genetic variants pathogenicity
16. Statistical problems in population-based biomedical research (e.g. case-control): population stratification, correction for 'test' multiple tests, missing data, epistasis, etc..
17. Epidemiological aspects on the basis of population genetic study (power, sampling, etc..)
1. Cavalli-Sforza LL, Menozzi P, Piazza A (1994) The history and geography of human genes. Princeton University Press, Princeton, New Jersey
2. Goldstain D, Schlotterer C (2001) Microsatellites: evolution and application. Oxford University Press, Great Britain
3. Hartl y Clark, “Principles of Population Genetics”, Ed. Sinauer Associates 1997.
4. Hartl, “A Primer of Population Genetics”, Ed. Sinauer Ass. 1988.
5. Hedrick, “Genetics of Populations”, 2nd edition, Ed. Jones and Bartlett Publishers .1999.
6. Jan Klein, Naoyuki Takahata (2002) Where do we come from? The molecular evidence for human descent., Springer
7. Nei y Kumar, “ Molecular evolution and phylogenetics”, Ed. Oxford University Press 2000.
Students should be able to achieve competencies and skills as mentioned below:
1. Strength in the basics of population genetics
2. Fluency and accuracy in oral and written communication skill of the concepts related to the subject; if possible, both in the mother tongue and in English
3. Adequate abilities for reading of a scientific text on population genetics
4. Capacity for analysis and synthesis
5. Ability to easily obtain and analyze information from various sources (books, magazines, Internet)
6. Critical capacity to a problem or a scientific text
7. Be able to apply the acquired knowledge to the future development of professional activities as genetic diagnosis, genetic counseling, biomedical research, etc..
8. Ability to develop, express and defend a reasoned ideas
9. Skill and capacity for teamwork
1. Lectures. Students can interrupt the teacher's explanations to intervene, claiming seek clarification or additional information. Also, the teacher may require the student participation in the discussion.
2. Problems. Well in advance will be made practical problems. Students handed the teacher the problems and solutions. Problems will be discussed in classes.
3. Practice. Labs may be made in sessions of one hour. Try practices a topic of bioinformatics analysis of population genetic data.
4. Monographs. Each student may submit a paper with a review of his on a genetic issue addressed by specialized journals. Monographs are individual work and the teacher will guide the student on the literature search and job performance. The work will be presented printed and have a maximum of 10 pages including bibliography and figures (if any).
5. Discussion groups. The students organized themselves. Groups consist of 3-4 students and will discuss for half an hour a topic related to population genetics in biomedicine. The discussion will be held in public and will be moderated by the teacher. The group must submit a three-page summary of the subject to be treated, citing bibliography and emphasizing the points or aspects of discussion items. The summary will be given at least one week in advance the presentation, and will be exhibited in a place accessible to the other students.
6. Other activities. Students may engage in other activities suggested by themselves and to be scoring, provided they have the approval of the teacher.
7. Personalized tutoring. Students may make inquiries and propose new activies to the subject. This activities have to be approved by the teacher.
8. Literature searches. Expand the content of the lectures and problems to the complementary activities. Preferably be conducted in the library of the Faculty of Medicine and via the Internet from the computer rooms of the Faculty.
The evaluation of the subject requires the presence of the student to a minimum of 80% of the classes.
The evaluation will be done taking into account the work done by the student during the course in relation to:
- Effort, involvement and participation in daily work
- The solution of practical problems formulated in the classes
- The preparation and discussion of scientific articles
- Monographic works carried out individually or in groups
3 ECTS, calculating 27 hours per credit. There is therefore a total of 81 hours would be as follows:
1. Theory: 24 hours classroom and 36 hours of personal work (total hours: 60)
2. Practical classes: 8 hours classroom and 10 hours of personal work (total hours: 18)
3. Custom Tutorials: 1 hour.
4. Theoretical and practical exams: 2 hours
1. Attendance and active participation in lectures and practicals
2. Continued study of the subject taught. Be used for that appropriate bibliography complement the subject taught in class.
3. Clarification regarding teacher all doubt may arise related to the subject
Antonio Salas Ellacuriaga
Coordinador/a- Department
- Forensic Science, Pathological Anatomy, Gynaecology and Obstetrics and Paediatrics
- Area
- Legal and Forensic Medicine
- Phone
- 881812230
- antonio.salas [at] usc.es
- Category
- Professor: University Professor
| Wednesday | |||
|---|---|---|---|
| 09:30-10:30 | Grupo /CLE_01 | Spanish | R.N.S.-Classroom 10 |