Chemistry applied to biology

Get the students:
To understand and to learn the most important concepts related to the structures, properties and most outstanding transformations of the most relevant chemical species in Biology.
To know how to apply such a knowledge to interpret and rationalize biological processes.

GENERAL CONTENTS OF THE SUBJECT:
* Composed of biological interest: structure and properties.
* Biological processes: characteristics and transformations more notable.
* Introduction to some of the most notable technicians of study of the biological compounds and his
processes.

CLASSES EXPOSITIVAS And INTERACTIVE CLASSES OF SEMINAR:
CONTENTS And APPROXIMATE TIME DEDICATION.
1. Chemical species of biological interest: structure, representation, visualization, nomenclature. 6 hours (3 expositivas + 2 seminars)
2. Isomery. Estereoquímica. Properties related. 4 hours (2 expositivas + 2 seminars)
3. Strengths (interactions) in the biological systems and his importance: links, formings, deslocalización, aromaticidad, solubility, added molecular. 6 hours (4 expositivas + 2 seminars)
4. Biological processes. Examples. Characteristics: kinetical and thermodynamic requirements. 4 hours (4 expositivas + 1 seminar)
5. Acids and bases. 4 hours (2 expositivas + 2 seminars)
6. Replacement nucleófila alifática. Transfer of phosphate. 3 hours (2 expositivas + 1 seminar)
7. Reactions of addition to the group carbonilo. Reactions of replacement in the group acilo. Reactions in alpha to groups carbonilo. 3 hours (2 expositivas + 0,5 seminars)
8. Reactions of oxidation and reduction. 3 hours (2 expositivas + 0,5 seminars)
9. Introduction to some of the most notable technicians: to) of separation/purification of biomoléculas (lisis cellular, centrifugation, precipitation, chromatographic, DNA recombinante, electroforéticas, crystallization) and b) of structural determination (EMAR, espectroscópicas - GO, UV, RMN-, diffraction of RX, criomicroscopía electronic). 4 hours (3 expositivas + 1 seminar)
10. Resolution individualizada face-to-face and written of questions and exercises of the sections 1, 2 and 3 up indicated. 1 hour (1 seminar)
11. Resolution individualizada face-to-face and written of questions and exercises of the sections 4, 5 and 6 up indicated. 1 hour (1 seminar)

PRACTICAL OF LABORATORY.
An introductory session: it will argue the work to carry out corresponding to each one of the sessions, some appearances of security and of the system of evaluation. 1 hour.
Three face-to-face sessions in the laboratory. 9 hours.
Separation. Basic sour/extraction. Leak to empty. Dried of dissolutions. Rotavapor.
Chromatography in fine layer. Synthesis 1. Identification and structural characterization.
Reactivity and synthesis 2.
PRACTICES OF COMPUTER.
Two virtual sessions synchronous (TEAMS). 6 hours.
Each student will make his work of individual form and will present it at the end of each session by means of the sending of a file through the virtual classroom.
Incorporation to a document of text in format TFG of molecules of biological importance represented in 2D (ChemDraw) and recent bibliographic information recopilada on them (articles of review..., etc.).
Incorporation to an oral presentation of names, formulas and molecules in 2D and 3D (configurations, formings) and of interactions of molecules of biological importance with proteins.

TUTORÍAS.
Two virtual sessions synchronous (TEAMS) devoted to resolve doubts, in particular those related with the resolution written individualizada of questions and exercises by each student (sections 10 and 11 up indicated). 1 hour (30 minutes by session).

BASIC BIBLIOGRAPHY

All the material of basic study, in particular the theoretical contents and the exercises proposed for each one of the subjects, as well as a guion of practise and links to on-line content, will be available in the virtual classroom of the subject.
For the practical classes of computer the students have to, besides, download to his personal computer teams the programs ChemDraw and Chem3D, of which the USC possesses a license Campus, following the instructions given in the virtual classroom.

COMPLEMENTARY BIBLIOGRAPHY

THEORY

Chemistry for the Life Sciences
Second eddition
Raul Sutton, Bernard Rockett & Peter Swindles
Library Intercentros, Campus of Lugo, QUI 437

BIOS Instant Notice in Chemistry for Biologists
J. Fisher, J. R. P. Arnold, Julie Fisher, and John Arnold
https://ebookcentral-proquest-com.ezbusc.usc.gal/lib/buscsp/detail.acti…

Organic Chemistry with to Biological Emphasis
Timothy Soderberg
University of Minnesota Morris Digital Well 2016
https://sites.google.com/morris.umn.edu/timsoderberg/home/organic-chemi…

Virtual Textbook of Organic Chemistry
https://cv.usc.es/mod/url/view.php?id=1078424

PROBLEMS

Problems of chemistry for students of biology
Mª Josefa Rodríguez Yunta, Lucrecia Campayo Pérez, Mª of Carmen Cano Benjumea, Ana Mª Sanz Square
Ed. Synthesis, D.L. 2013
ISBN 978-84-995886-8-1
Library of Bioloxía: To Q 71, To Q 71 To and To Q 71 B

interactive Exercises: Functional Groups.
https://cv.usc.es/mod/url/view.php?id=1078428

Interactive exercises: Nomenclature
https://cv.usc.es/mod/url/view.php?id=1078429

ChemTube3D: chemical structures and interactive animations of mechanisms of reaction in 3D.
https://cv.usc.es/mod/url/view.php?id=1078425

PRACTICAL OF LABORATORY
1. Martínez Grau, Mª Á. And Csákÿ, To. G., “experimental Technicians in organic synthesis”, Ed. Synthesis, Madrid, 2001-2008.
2. R.H. Petrucci, W.S. Harwood And F.G. Herring, “General Chemistry”; 8ª ed., Ed. Prentice Hall, 2003.

KNOWLEDGE/CONTENTS:
Con02: To know and understand the physico-chemical principles of Biology.

SKILLS/ABILITIES:
H/D01: Apply the theoretical and practical knowledge acquired in an integrated manner
in the transmission of information/ideas and in the approach and resolution of
problems, both in academic and professional contexts.
H/D08: Ability to reason, argument, and critical thinking.
H/D11: Ability to produce and present an organized and comprehensible text,
adequately reflecting the sources of information used.

COMPETENCES:
Comp02: That students have developed those skills
necessary to undertake further studies with a high degree of
autonomy.

The subject will have a virtual classroom employing the platform MOODLE, in which it will include all the educational material of the course, the time planning, the links to pages of interest, etc., and that will constitute the half preferential of communication with the students. For the synchronous virtual activities will employ the platform “TEAMS”.

In the classes expositivas, face-to-face and of assistance no compulsory, the methodology prevalente will be the one of "masterclass", in which, nevertheless, will promote the participation of the students in the resolution of questions and exercises to apply and consolidate the concepts entered. In the measure in which the students answered to the proposal that they work the contents and concepts home, for later proceed in class to the resolution of the doubts and of the questions and exercises mentioned associated to said contents, would apply also a methodology of "classroom invested".
To such end, and through the virtual classroom, the students will have prior to the classes of all the material of precise study, including the essential information, structured and more current possible on each one of the contents collected of way numbered in the section of the same name of this guide, as well as the proposal of questions and exercises to resolve.

In the face-to-face interactive classes of seminar will promote the resolution of questions and exercises/problems by part of the students; in two of such interactive classes of seminar the students will make an exercise written and individualizado that will be described with 1 point each one in the final note.
The assistance to the interactive classes of seminar is optional, but the no realization of each one of the two exercises written individualizados will suppose the renunciation to the point assigned to the same in the final note (for more details on the evaluation, read the corresponding section devoted to the subject in this guide)

The classes of tutoría (of assistance no compulsory and given of synchronous virtual way), devoted to the resolution of doubts, will be scheduled so that each one of them take place shortly after each one of the seminars devoted to the resolution written and individualizada already quoted.

So much the practices of computer like the ones of laboratory are of compulsory assistance; his execution is necessary condition to approve the subject (more details in the section of evaluation of this guide).
The access to the laboratory for the realization of the practical could be conditioned to the superación of a previous on-line exercise related with appearances such like norms of security, material, etc.
The practices of computer will be given of synchronous virtual way.

CONTINUOUS EVALUATION
Two controls will be carried out during two of the theoretical classes, which will contribute with a mark of up to 2 points to the final grade out of 10; The mark of the controls will be applied both for the ordinary assessment and for the second chance.
Students with justified cause are exempt from carrying out the controls: students who have been granted exemption from attending face-to-face classes or students who can provide documentary proof of the impossibility of attendance due to force majeure.

PRACTICAL WORK
Final practical grade = up to a maximum of 1 point to the final grade out of 10, distributed as indicated below.
The work done by each student during the two computer sessions, collected in two files, will be evaluated and will contribute up to 0.2 points to the final grade of the subject.
The performance of each student in the three laboratory sessions (which may include the following aspects: previous work, attitude, dexterity and ability, organization and handling of tools and materials, understanding of techniques and concepts, notes in the Laboratory notebook, answers to the questions at the end of the scripts), will be evaluated and will contribute up to 0.3 points to the final grade of the subject.
The final written exam of the practical work, to be taken immediately after the final written theory exam and which may include any concept related to the practical work or any technique/protocol used during the practical work, and will evaluate the understanding and retention of what has been learned, will contribute up to 0.5 points to the final grade of the subject.
The grade of the practical work will be applied both for the ordinary evaluation and for the second opportunity.
The completion of the practical work at 100% is mandatory.
Students who have not completed the practical workwill receive a maximum final grade of 4.0 (fail) out of 10.
Repeating students who have completed the practical workof this subject or of the annual subject of the same name ("Chemistry for Biologic") in previous years will be exempt from its repetition; In this course, they will be assigned the grade of practical workthat they had previously obtained.

FINAL WRITTEN EXAMINATION (items 1-9)
It will contribute with up to 7 points to the final grade out of 10.

FINAL GRADE
To pass the subject, it is necessary to meet each and every one of the three requirements A, B and C, which are indicated below:
A. Obtain a minimum grade of 4 points out of 10 (2.8 points out of 7) in the final written exam of topics 1-9.
B. Obtain a final grade of 5 points out of 10; The final grade out of 10 is the sum of the mark of the controls (up to 2 points), the practical work mark (up to 1 point) and the mark obtained in the final written exam of topics 1-9 (up to 7 points).
C. Have completed the practical work. The maximum final grade to be recorded in the transcript of the subject for students who have not completed the practical work will be four points (fail) out of 10.

FRAUDULENT PERFORMANCE OF ASSESSMENT TESTS
In cases of fraudulent completion of exercises or tests, the provisions of the "Regulations for the assessment of the academic performance of students and the review of qualifications" will apply, in particular:
"Fraudulent conduct in any exercise or test required in the evaluation of a subject will result in a grade of failure in the corresponding call, regardless of the disciplinary process that may be followed against the offending student."

CONDUCTING TELEMATIC TESTS THROUGH TEAMS
(identification and oral assessment of students through TEAMS)
To take any synchronous online test, all students who wish to participate:
1st. They must previously join the TEAMS session (which will be opened for this purpose associated with this test) by means of a team that has a camera and microphone, and attend to any identification requirements of the teaching staff.
2nd. You will need to stay connected to the TEAMS session during the telematics test run.
3rd. They must remain in the TEAMS session for half an hour after the end of the online test, a period in which they can be orally evaluated the content of the online test.

COMPETENCY ASSESSMENT
Competencies Con02, H/D01 and H/D08 will be assessed in continuous assessment controls and final exams.
Competencies H/D11 and Comp02 will be assessed in the computer and laboratory practices.

The matter has 6 credits ECTS,
this is,
a total of 150 (6 x 25) total hours of study and work of the students,

of which 58 are face-to-face,
distributed of the following way = 24 hours expositivas + 14 interactive hours of seminar + 10 hours of practices of laboratory+ + 6 hours of practices of computer + 1 hour of tutorías + 3 hours of final examination,

and 92 are hours of personal work no face-to-face,
for which proposes the following distribution = 36 hours of previous work to the classes expositivas (1,5 h of previous work by each one of the 24 classes expositivas) + 28 hours of previous work to the interactive classes of seminar (2 hours of previous work by each one of the 14 seminars) + 6 hours of previous work to the practical classes + 22 hours of preparation of examinations.

It is highly recommended:
• Attendance and active participation at every teaching event.
• To work the content assigned to each class (in the planning file available in the virtual classroom) prior to the celebration of said class.
• The use of molecular models and computer programs for the representation/visualization of molecules in 2D and 3D.

The knowledges of chemistry that the students can have like result of previous studies to the degree in Biology will facilitate, definitely, the superación of this matter, but are not indispensable requirement to tackle it and surpass it if the students works following the instructions of this guide.

The matter will have a virtual classroom employing the platform MOODLE, in which it will include all the educational material of the course, calendars, links to pages of interest, etc., and that will constitute the half preferential of communication with the students.
For the synchronous virtual activities will employ the platform “TEAMS”.